Antisense Drug Technology: Principles, Strategies, and by Stanley T. Crooke PDF

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By Stanley T. Crooke

generally revised and up-to-date, Antisense Drug know-how: rules, concepts, and purposes, moment Edition displays the logarithmic development made long ago 4 years of oligonucleotide-based treatments, and, particularly, antisense therapeutics and examine. analyzing classes discovered from the scientific trials of first iteration medications, the booklet evaluates the expertise as a complete and gives new instructions and avenues of analysis and improvement.

Divided into 5 components, the ebook starts with an intensive advent to the mechanism of antisense drug motion together with the RNase H mechanism, small RNA silencing pathways, and the capability therapeutics of splice switching oligonucleotides. prime researchers show the fundamentals of oligonucleotide therapeutics partially by means of delineating medicinal chemistry, pharmacokinetics, and supply routes corresponding to liposomal formulations for nucleic acid delivery.  half 3 info hybridization established medicinal drugs and considers the dramatic advances represented by way of 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA medicines. different chemical periods of gear and mechanisms of motion are defined partly 4 with additional discussions on enhancing the second one iteration antisense medicinal drugs. the ultimate half delves deeply into healing purposes. Contributing authors study the opportunity of antisense medications for the relief of cardiovascular ailments, metabolic ailments, inflammatory illnesses, melanoma, neurological problems, and immune modulation.

Presenting a hugely targeted, lucid dialogue of the notable advances within the box, Antisense Drug know-how: rules, ideas, and functions, moment Edition offers the platform for researchers to proceed to aggressively pursue the good chance represented by means of this intriguing technology.

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Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition by Stanley T. Crooke

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